Publications & Scientific Presentations

Dr. Jennifer Wargo: Understanding Responses to Cancer Immunotherapy: The tissue is the issue, but the scoop is in the poop Yale Center for Immuno-Oncology.

Dr. Jennifer Wargo: Association Between Gut Microbiome and Responses in Melanoma Patients on Anti-PD-1 Therapy

Prof. Gal Markel: Reverse personalized immuno-oncology: A new paradigm

Prof. Gal Markel: TEDMed: Immuno-oncology is going to revolutionize cancer treatment

2021

2020

The human tumor microbiome is composed of tumor type–specific intracellular bacteria. Science.
Nejman, D., Livyatan, I., Fuks, G., Gavert, N., Zwang, Y., Geller, L. T., Wargo JA., Segal E … Straussman, R.

 Gut microbiome modulation via fecal microbiota transplant to augment immunotherapy in patients with melanoma or other cancers. Current oncology reports (2020)
McQuade JL, Ologun GO, Arora R, Wargo JA.

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Science.‏
Baruch, E. N., Youngster, I., Ben-Betzalel, G., Ortenberg, R., Lahat, A., Katz, L., … Boursi, B & Markel G.

2019

Modulating the microbiome to improve therapeutic response in cancer. The Lancet Oncology.
Helmink BA, Khan MW, Hermann A, Gopalakrishnan V, Wargo JA.

Structural variation in the gut microbiome associates with host health. Nature.
Zeevi D, Korem T, Godneva A, Bar N, Kurilshikov A, Lotan-Pompan M, Weinberger A, Fu J, Wijmenga C, Zhernakova A, Segal E.

Fecal microbiota transplantation (FMT) and re-induction of anti-PD-1 therapy in refractory metastatic melanoma patients-preliminary results from a phase I clinical trial (NCT03353402). Presentation_AACR Annual Meeting 2019. Abstract CT042 Baruch EN, Youngster I, Ortenberg R, Ben-Betzalel G, Katz LH, Lahat A, Barshack I, Dick-Necula D, Mamtani R, Bloch N, Ungar B, Markel G.

Fecal Microbiota Transplantation in Metastatic Melanoma Patients Resistant to Anti-PD-1 Treatment. Open Forum Infectious Diseases .Supplement, Vol. 6, pS7-S7. 1p Youngster I, Baruch E, Katz L, Lahat A, Brosh-Nissimov T, Schachter J, Koren O, Markel G, Boursi B.

2018

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis. Nature medicine.
Wang Y, Wiesnoski DH, Helmink BA, Gopalakrishnan V, Choi K, DuPont HL, Jiang ZD, Abu-Sbeih H, Sanchez CA, Chang CC, Parra ER.

The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer cell.
Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA.

2017

Microbiome at the frontier of personalized medicine. Elsevier
Kashyap PC, Chia N, Nelson H, Segal E, Elinav E.

2016

Taking it personally: personalized utilization of the human microbiome in health and disease. Cell host & microbe.
Zmora N, Zeevi D, Korem T, Segal E, Elinav E.